ChloroquineV1, France, Analysis, bibRecord, 000105

Gold(I) complexes bearing phosphole ligands: Synthesis and antimalarial activity

Identifieur interne : 000105 ( France/Analysis ); précédent : 000104; suivant : 000106

Gold(I) complexes bearing phosphole ligands: Synthesis and antimalarial activity

Auteurs : K. Fourmy [France] ; M. Gouygou [France] ; O. Dechy-Cabaret [France] ; F. Benoit-Vical [France]

Source :

Comptes Rendus Chimie [ 1631-0748 ] ; 2017.

RBID : Hal:hal-01939179

Abstract

A series of gold(I)-monophosphole complexes have been synthesized and characterized. The introduction of a nitrogen moiety in the complex structure was envisioned either by choosing the bis(trifluoromethanesulfonyl)imidate ligand as the X-ligand or by preparing a new pyrrolidinophosphole ligand as the L-ligand. All the complexes have been evaluated in vitro for their antimalarial activity. These gold–phosphole complexes showed moderate activities with IC50 values ranging from 9.7 to 24 μM against Plasmodium falciparum chloroquine-resistant strains.

Url:

https://hal.archives-ouvertes.fr/hal-01939179

DOI: 10.1016/j.crci.2016.06.008

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000105
to stream Hal, to step Curation: 000105
to stream Hal, to step Checkpoint: 000064
to stream Main, to step Merge: 000C78
to stream Main, to step Curation: 000C78
to stream Main, to step Exploration: 000C78
to stream France, to step Extraction: 000105

Links to Exploration step

Hal:hal-01939179

Le document en format XML

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<tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.crci.2016.06.008</idno>
<series><title level="j">Comptes Rendus Chimie</title>
<idno type="ISSN">1631-0748</idno>
<imprint><date type="datePub">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>A series of gold(I)-monophosphole complexes have been synthesized and characterized. The introduction of a nitrogen moiety in the complex structure was envisioned either by choosing the bis(trifluoromethanesulfonyl)imidate ligand as the X-ligand or by preparing a new pyrrolidinophosphole ligand as the L-ligand. All the complexes have been evaluated in vitro for their antimalarial activity. These gold–phosphole complexes showed moderate activities with IC50 values ranging from 9.7 to 24 μM against Plasmodium falciparum chloroquine-resistant strains.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Fourmy, K" sort="Fourmy, K" uniqKey="Fourmy K" first="K." last="Fourmy">K. Fourmy</name>
</noRegion>
<name sortKey="Benoit Vical, F" sort="Benoit Vical, F" uniqKey="Benoit Vical F" first="F." last="Benoit-Vical">F. Benoit-Vical</name>
<name sortKey="Dechy Cabaret, O" sort="Dechy Cabaret, O" uniqKey="Dechy Cabaret O" first="O." last="Dechy-Cabaret">O. Dechy-Cabaret</name>
<name sortKey="Gouygou, M" sort="Gouygou, M" uniqKey="Gouygou M" first="M." last="Gouygou">M. Gouygou</name>
</country>
</tree>
</affiliations>
</record>

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Gold(I) complexes bearing phosphole ligands: Synthesis and antimalarial activity

Gold(I) complexes bearing phosphole ligands: Synthesis and antimalarial activity

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